Synonyms | 46 kDa mannose 6-phosphate receptor, MPR46, MPRD, CD Man-6-P receptor, CD-MPR |
Swiss Prot Num | P20645 |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-term region of human M6PR. |
Product Type | Antibodies |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
References | 1. Perez-Victoria,F.J., Mol. Biol. Cell 19 (6), 2350-2362 (2008) 2. Mari,M., Traffic 9 (3), 380-393 (2008) 3. Lemansky,P., J. Leukoc. Biol. 81 (4), 1149-1158 (2007) 4. Chen,J.J., Cell 119 (7), 915-926 (2004) |
|
Format | State: Liquid purified Ig fraction. |
? | Purification: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. |
? | Buffer System: PBS with 0.09% (W/V) Sodium Azide as preservative. |
|
Specificity | This antibody detects M6PR (N-term). |
Add. information | Molecular weight: 30993 Da |
Application | ELISA: 1/1,000. Immunohistochemistry: 1/10-1/50. |
Background | M6PR is a receptor for mannose-6-phosphate groups on lysosomal enzymes. The receptor forms a homodimer or homotetramer for intracellular targeting of lysosomal enzymes and export of newly synthesized lysosomal enzymes into the cell secretions. The receptor is an integral membrane protein which localizes to the trans-Golgi reticulum, endosomes, and the plasma membrane. |
Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Concentration | 0.25 mg/ml |