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| Cat. No |
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Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-370182 |
H00000999-A01 |
E Cadherin Antibody//Human/Mouse |
1/EA |
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문의 |
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Subject
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E Cadherin Antibody |
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Description
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/ Human/Mouse |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | WB, ELISA | | Clonality: | Polyclonal | | | Gene: | CDH1 | | Purity: | Whole antisera | | Host: | Mouse | | | Specificity: | CDH1 - cadherin 1, type 1, E-cadherin (epithelial) | Details: | Immunogen: | CDH1 (NP_004351, 381 a.a. ~ 481 a.a) partial recombinant protein with GST tag. | | Epitope: | KGQVPENEANVVITTLKVTDADAPNT PAWEAVYTILNDDGGQFVVTTNPVNN DGILKTAKGLDFEAKQQYILHVAVTN VVPFEVSLTTSTATVTVDVLDV* | Gene Symbol: CDH1 | Entrez: | 999 (Human) | | Omim: | 137215|192090 (Human) | | Swiss Prot: | NP_004351 (Human) | | Related Genes: | CTNNB1, CTNNA1, APC, CDKN2A, PROC, TP53, SLC22A3, ITK, EGFR, VIM, JUP, FZR1, HGF, TJP1, ERBB2, CD44, VEGFA, MMP9, AKT1, RASSF1, MLH1, CCND1, EGF, CDKN1A, OCLN, CTNND1, PIK3CG, GSTP1, MGMT, PCNA, MYC, BCL2, SUB1, SNAI2, CDKN2B, IL6, CDC20, SRC, MMP-2, MMP2 | Background: This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites. Species: | Reactivity: | Human. Other species not tested. | Applications: | Uses: | The quality control of this antibody is limited to Western blot on the immunizing protein. It has also been used for ELISA. Abnova's recommended working dilutions for western analysis are as follows:1:500 dilution for ascites1:1000 for purified Ig1:500-1:1000 for polysera | | Dilutions: | ELISA,Western Blot 1:500 | Notes: This product is produced by and distributed for Abnova, a company based in Taiwan. Packaging: | Buffer: | This antibody is in antisera and the concentration is unavailable. | | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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