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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-376551 |
H00003426-D01P |
Factor I Antibody//Human/Rabbit |
1/EA |
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¹®ÀÇ |
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Subject
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Factor I Antibody |
Description
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/ Human/Rabbit |
Clonality
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Poly |
Company
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Novus biologicals |
Application
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ELISA, Western Blot |
Conjugation
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Immunogen
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Contents
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Description:Summary: Protein Type: | Full length Protein | Species: | Hu | Applications: | WB, ELISA | Clonality: | Polyclonal | | Gene: | CFI | Purity: | protein A purified | Host: | Rabbit | | Specificity: | Reacts with complement factor I. | Details: Immunogen: | CFI (AAH20718.1, 1 a.a. ~ 377 a.a) full-length human protein. | Epitope: | MKLLHVFLLFLCFHLRFCKVTYTSQE DLVEKKCLAKKYTHLSCDKVFCQPWQ RCIEGTCVCKLPYQCPKNGTAVCATN RRSFPTYCQQKSLECLHPGTKFLNNG TCTAEGKFSVSLKHGNTDSEGIVEVK LVDQDKTMFICKSSWSMREANVACLD LGFQQGADTQRRFKLSDLSINSTECL HVHCRGLETSLAECTFTKRRTMGYQD FADVVCYTQKADSPMDDFFQCVNGKY ISQMKACDGINDCGDQSDELC | Gene Symbol: CFI Entrez: | 3426 (Human) | Swiss Prot: | AAH20718.1 (Human) | Related Genes: | CFH, Cfh, Cfi, Cfi, C3, Olfr48, C3, C3, Cfb, C4b, C4b, Cr2, C4B, CD46, Cd46, Cd46, CR1, Atp5s, Cr1l, Hc, C5, Tdgf1, C4A, CFB, Cr1l, Cfb, C5, CAPG, CFP, F2, Tnf, CD55, C4BPA, C4bpa, C4bp, Tnf, C4BPB, Cd55, C2, Cd55 | Background: This gene encodes a serine proteinase that is essential for regulating the complement cascade. The encoded preproprotein is cleaved to produce both heavy and light chains, which are linked by disulfide bonds to form a heterodimeric glycoprotein. This heterodimer can cleave and inactivate the complement components C4b and C3b, and it prevents the assembly of the C3 and C5 convertase enzymes. Defects in this gene cause complement factor I deficiency, an autosomal recessive disease associated with a susceptibility to pyogenic infections. Mutations in this gene have been associated with a predisposition to atypical hemolytic uraemic syndrome, a disease characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Primary glomerulonephritis with immmune deposits is another condition associated with mutation of this gene. [provided by RefSeq] Species: Applications: Uses: | This antibody is reactive against transfected lysate in western blot, and as a detection antibody in ELISA. | Dilutions: | ELISA,Western Blot | Notes: Genbank Accession: BC020718.1 This product is produced by and distributed for Abnova, a company based in Taiwan. Packaging: Buffer: | 1x PBS, pH 7.2 | Storage: | Store at -20C. Avoid freeze-thaw cycles. | Preservative: | No Preservative | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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