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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-376555 |
NBP1-21516 |
Factor I Antibody//Human/Sheep |
1/EA |
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¹®ÀÇ |
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Subject
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Factor I Antibody |
Description
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/ Human/Sheep |
Clonality
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Poly |
Company
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Novus biologicals |
Application
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ID |
Conjugation
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Immunogen
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Contents
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Description:Summary: Species: | Hu | Applications: | ID | Clonality: | Polyclonal | | Gene: | CFI | Purity: | IgG purified | Host: | Sheep | | Specificity: | NBP1-21516 recognizes Complement Factor I, a member of the peptidase S1 family present in the blood plasma. Factor I is an 88 kDa protein consisting of one polypeptide chain of 35.4 kDa and one of 27.6 kDa. Factor I is a serine protease which inactivates complement components C3b and C4b. C3b cleavage requires the presence of cofactors complement component (3b/4b) receptor 1 (CR1), membrane cofactor protein or factor H, while C4b cleavage requires complement component 4 binding protein or CR1. Factor I has no natural inhibitors. Dysfunctional factor I can lead to uncontrolled activation of the alternative complement pathway causing systemic depletion of C3 and lowering levels of factors B and H, resulting in recurrent pyogenic infections. Defects in CFI are also associated with haemolytic uraemic syndrome. This reagent is also available as nephelometric grade whole serum and in bulk quantities. Please enquire for further details. | Details: Isotype: | IgG | Immunogen: | Human Factor I purified from plasma | Gene Symbol: CFI Entrez: | 3426 (Human) | Related Genes: | CFH, Cfh, Cfi, Cfi, C3, Olfr48, C3, C3, Cfb, C4b, C4b, Cr2, C4B, CD46, Cd46, Cd46, CR1, Atp5s, Cr1l, Hc, C5, Tdgf1, C4A, CFB, Cr1l, Cfb, C5, CAPG, CFP, F2, Tnf, CD55, C4BPA, C4bpa, C4bp, Tnf, C4BPB, Cd55, C2, Cd55 | Background: Factor I is a plasma protein of molecular weight 88 kDa, consisting of two disulphide linked chains of 50 and 38 kDa. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It has a requirement for protein cofactors for cleavage of these complement proteins, Factor H, CR1 or MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage. Factor I is a plasma protein of molecular weight 88 kDa, consisting of two disulphide linked chains of 50 and 38 kDa. Factor I is a serine protease with a high degree of specificity for C3b and C4b. It has a requirement for protein cofactors for cleavage of these complement proteins, Factor H, CR1 or MCP are required for C3b cleavage and C4bp or CR1 for C4b cleavage. Species: Applications: Uses: | Immunodiffusion | Dilutions: | Immunodiffusion | Packaging: Buffer: | Glycine buffered saline, 0.01% Benzamidine, 0.1% EACA, 1mM EDTA | Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | Preservative: | 0.09% Sodium Azide | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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