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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-376622 |
NB100-428C |
Factor Inhibiting HIF-1 Antibody [DyLight 649]//Human, Rat/Rabbit |
1/EA |
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문의 |
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Subject
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Factor Inhibiting HIF-1 Antibody [DyLight 649] |
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Description
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/ Human, Rat/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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IHC-P, IP, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Rt, Hu | | Applications: | WB, IP, IHC | | Clonality: | Polyclonal | | | Gene: | HIF1AN | | Purity: | Immunogen affinity purified | | Host: | Rabbit | | | Specificity: | This is specific for FIH-1 protein. | | Publications: | Antibody has not yet been mentioned in a publication. | Details: | Conjugate: | DyLight 649 | | Immunogen: | A C-terminal region synthetic peptide made to the human FIH protein sequence (between residues 300 and the C-terminus). | | Localization: | Nuclear | Gene Symbol: HIF1AN | Entrez: | 55662 (Human) | | Swiss Prot: | Q9NWT6 (Human) | | Related Genes: | HIF1A, Hif1a, Hif1a, CASR, SETD2, Vegfa, VEGFA, Vegfa, VHL, Vhl, Egln1, EGLN1, Epo, EPO, Egln1, Epo, Ep300, EP300, Vhl, EGLN3, Egln3, Egln3, Notch1, Car9, CA9, Nfkb1, NFKB1, Epas1, Crebbp, Notch1, Nfkb1, ADI1, CUX1, NOTCH1, NOTCH4, PAG1, OPN1LW, EPX, TIMP1, Notch2 | Background: Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration. Species: | Reactivity: | Human and rat. | Applications: | Uses: | In Western Blot, a band at ~40.3 kDa is seen. This antibody may be used in immunohistochemistry on rat brain tissue. Other applications have not yet been tested. | | Dilutions: | immunohistochemistry 1:100, immunoprecipitation , Western Blot 1:1,000-1:5,000 | | Concentrations: | 1.25 mg/ml | | Conjugated Ab's: | 4 conjugated antibodies | Packaging: | Buffer: | 50mM sodium borate | | Storage: | Store at 4C. Do not freeze. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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