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14-3-3 protein pan

Brand : Acris Antibodies GmbH

Cat. No	Model	Description	Unit	Price (VAT별도)	납기	재고	DataSheet	주문/견적
LCA-24-366884	AP05930PU-N	14-3-3 protein pan//Human, Mouse, Rat, Bovine, Canine, Chicken, Monkey/Rabbit	1/EA					문의

Subject

14-3-3 protein pan

Description

/ Human, Mouse, Rat, Bovine, Canine, Chicken, Monkey/Rabbit

Clonality

Mono

Company

Acris Antibodies GmbH

Application

Western blot / Immunoblot

Conjugation

Immunogen

Contents

Description:

Manufacturer	Acris Antibodies GmbH
Quantity	0.1 ml
Reactivity	Human, Mouse, Rat, Bovine, Canine, Chicken, Monkey, Sheep, Xenopus, Zebrafish
Presentation	Purified
Applications	Western blot / Immunoblot
Isotype	IgG
Host	Rabbit
PDF datasheet	view
Shipping to	Worldwide

Synonyms	YWHA, FocusOn116
Immunogen	Synthetic phosphopeptide corresponding to an amino acid sequence within 14-3-3 protein which includes phosphorylated Ser58.
Product Type	Antibodies
Storage	Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
References	1. Dougherty, M.K. et al. (2004) Unlocking the code of 14-3-3. J. Cell Science. 117: 1875-1884. 2. Woodcock, J.M. et al. (2003) The dimeric versus monomeric status of 14-3-3zeta is controlled by phosphorylation of Ser58 at the dimer interface. J. Biol. Chem. 278: 36323-36327. 3. Yang, H. et al. (2006) DNA damage induced Protein 14-3-3 (sigma) inhibits Protein Kinase B/Akt activation and suppresses Akt-activated cancer. Cancer Res 66: 3096-3105.
Format	State: Liquid purified Ig
?	Purification: Affinity chromatography
?	Buffer System: 10mM HEPES, pH7.5 containing 0.09% Sodium Azide, 0.01% Bovine Serum Albumin, 50% Glycerol
Specificity	This antibody specifically recognises the 29kDa 14-3-3 protein, when phosphorylated at Ser58.
Application	Western Blot: 1:1000; detects a band of approximately 29kDa in rat brainstem cell lystates.
Background	The family of 14-3-3 proteins are highly conserved proteins expressed abundantly in the brain, which have been identified as crucial regulators of many cellular processes including multiple signalling pathways, cell growth, apoptosis, intracellular trafficking and malignant transformation. The interaction of 14-3-3 with target proteins is typically dependant upon phosphorylation, occurring through phosphoserine and phosphothreonine binding, with 14-3-3 protein activity itself being regulated by kinases such as kinase A and C, Akt, and CaMK1 and equally by phosphatases such as protein phosphatase 1 (PP1) and 2A (PP2A). The ability of 14-3-3 protein to facilitate the phosphorylation of Tau present in neurofibrillary tangles (NFTs) and the co-localisation of 14-3-3 protein with alpha-synuclein found in Lewy bodies, suggests a role for 14-3-3 protein in the pathogenesis of both Alzheimer
Caution	(A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Focuson	116 Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta)