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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-366889 |
AP05571SU-N |
14-3-3 protein theta//Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep/Rabbit |
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Subject
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14-3-3 protein theta |
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Description
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/ Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 ml | | Reactivity | Human, Mouse, Rat, Bovine, Chicken, Rabbit, Sheep | | Presentation | Serum | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Isotype | IgG | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | 14-3-3 protein tau, 14-3-3 protein T-cell, YWHAQ, Protein HS1, FocusOn116 | | Swiss Prot Num | P27348 | | Immunogen | Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 tau/theta | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Martin, H. et al. (1993) Antibodies against major brain isoforms of 14-3-3 protein. An antibody specific for the Nacetylated aminoterminus of a protein. FEBS 331: 296 - 303. 2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162 - 172. | |
| Format | State: Liquid serum containing 0.09% Sodium Azide (NaN3) | |
| Specificity | This antibody recognises 14-3-3 tau/theta in all mammals. This antibody may not react with recombinant proteins that are not Nacetylated. | | Application | Immunohistochemistry on paraffin sections: requires antigen retrieval using heat treatment prior to staining of paraffin sections. ELISA. Western Blot: detects a band of approximately 30kDa in HEK293 cell lysates. | | Background | 14-3-3 theta is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple cell signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preferences for itu™s different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 tau/theta is primarily expressed in Tcells although it occurs at lower levels in the brain, heart, pancreas placenta and kidneys. It plays a role in cell cycle progression via interaction with p27(Kip1). Along with COPI, the theta isoform binds the GB1 RSR sequence involved in protein trafficking. The isoform forms a complex with Hsp60 and cellular prion protein which may be involved in prion diseases. Elevated levels of 14-3-3 tau/theta are observed in amyotrophic lateral sclerosis. 14-3-3 tau/theta also binds BCR/Abl, bacterial effector protein Tir, yes-associated protein and the FSH receptor. | | Caution | (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only. | | Focuson | 116 Antibody Panel to Proteins of the 14-3-3 family (14-3-3 beta, 14-3-3 gamma, 14-3-3 epsilon, 14-3-3 zeta, 14-3-3 theta, 14-3-3 sigma, 14-3-3 eta) | |
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