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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-353506 |
NB110-60928B |
apg16 Antibody [Biotin]//Bovine, Canine/Rabbit |
1/EA |
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문의 |
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Subject
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apg16 Antibody [Biotin] |
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Description
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/ Bovine, Canine/Rabbit |
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Clonality
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Poly |
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Company
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Novus biologicals |
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Application
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Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Mu, Ca, Bv, Rt, Mk, Hu | | Applications: | WB | | Clonality: | Polyclonal | | | Gene: | ATG16L1 | | Purity: | peptide affinity purified | | Host: | Rabbit | | Details: | Conjugate: | Biotin | | Immunogen: | A synthetic peptide within residues 1-100 of the human protein. [Swiss-Prot# Q676U5] | | Localization: | Cytoplasm. Preautophagosomal structure, preautophagosomal structure membrane, peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. | Gene Symbol: ATG16L1 | Entrez: | 55054 (Human) | | Swiss Prot: | Q676U5 (Human) | | Related Genes: | NOD2, IL23R, IRGM, SLC22A5, SLC22A4, DLG5, ATG5, MAP1LC3A, ATG12, ACAD8, TLR4, NKX2-3, RAB33A, ABCB1, RAB33B, SQSTM1, TNFSF15, PTPN2, STAT3, IL12B, STK4, NOD1, TLR9, PTPN22, IL-23R, PHOX2B, FAM92B, ADIPOQ, LEP, ECM1, PPARA, NUP62, PTGER4, ATP7B, MST1, MAP3K1, NCF4, IGF2BP2, SLC4A1, CCNY | Background: Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). The APG12-APG5-APG16L complex is essential for the elongation of autophagic isolation membranes. This complex initially associates in uniform distribution with small vesicle membranes. During membrane elongation, the complex partitions, with a great concentration building on the outer side of the isolation membrane. Upon completion of the formation of the autophagosome, the APG12-APG5-APG16L dissociates from the membrane. There are 5 isoforms of this protein (in human), with theoretical molecular weights ranging from ~19-68 kDa. Species: | Reactivity: | Reacts with human, rat, bovine, canine, mouse and primate. | Applications: | Uses: | This antibody is useful for Western blot analysis, where a specific band is seen at ~68kDa. | | Dilutions: | Western Blot 0.5 - 2 ug/ml | | Concentrations: | 0.8 mg/ml | | Conjugated Ab's: | 4 conjugated antibodies | Packaging: | Buffer: | PBS | | Storage: | Store at 4C. Do not freeze. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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