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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-23-370238 |
H00001869-M01 |
E2F1 Antibody (2E10)//Human/Mouse |
1/EA |
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문의 |
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Subject
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E2F1 Antibody (2E10) |
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Description
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/ Human/Mouse |
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Clonality
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Mono |
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Company
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Novus biologicals |
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Application
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ELISA, Western Blot |
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Conjugation
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Immunogen
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Contents
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Description:Summary: | Species: | Hu | | Applications: | WB, ELISA | | Clonality: | Monoclonal | | | Gene: | E2F1 | | Purity: | IgG purified | | Host: | Mouse | | | Specificity: | E2F1 - E2F transcription factor 1 | Details: | Clone: | 2E10 | | Isotype: | IgG2a Kappa | | Immunogen: | E2F1 (NP_005216, 348 a.a. ~ 438 a.a) partial recombinant protein with GST tag. | | Epitope: | QSLLSLEQEPLLSRMGSLRAPVDEDR LSPLVAADSLLEHVREDFSGLLPEEF ISLSPPHEALDYHFGLEEGEGIRDLF DCDFGDLTPLDF* | Gene Symbol: E2F1 | Entrez: | 1869 (Human) | | Omim: | 189971 (Human) | | Swiss Prot: | NP_005216 (Human) | | Related Genes: | ARID4A, CDKN1A, CDKN2A, TP53, CDK2, E2F4, RB1, CDK4, E2F3, E2F2, CCND1, TCEAL1, D4S234E, RBL1, MYC, RBL2, TFDP1, CCNA2, PCNA, RAB3GAP1, NOLC1, E2F5, PAK3, DCTN6, SSSCA1, IFI27, PSMD9, MDM2, SLC12A9, CDKN1B, BCL2, DHFR, CDC2, CASP3, TP73, SP1, ARHGAP24, NOL3, BAX, DAND5 | Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. Species: | Reactivity: | Human. Other species not tested. | Applications: | Uses: | Antibody reactive against recombinant protein with GST tag on ELISA and Western Blot. GST tag alone is used as a negative control. | | Dilutions: | ELISA,Western Blot 1:500 | Notes: This product is produced by and distributed for Abnova, a company based in Taiwan. Packaging: | Storage: | Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. | | Preservative: | No Preservative | | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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