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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-23-370261 |
PAB0449 |
E2F1 [phospho Ser337] Antibody//Human/Rabbit |
1/EA |
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Subject
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E2F1 [phospho Ser337] Antibody |
Description
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/ Human/Rabbit |
Clonality
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Poly |
Company
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Novus biologicals |
Application
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IHC-P, Western Blot |
Conjugation
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Immunogen
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Contents
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Description:Summary: Protein Type: | Peptide | Species: | Hu | Applications: | IHC-P, WB | Clonality: | Polyclonal | | Gene: | E2F1 | Purity: | Whole antisera | Host: | Rabbit | | Specificity: | E2F1 - E2F transcription factor 1 [Ser337] | Details: Modification: | phospho Ser337 | Isotype: | IgG | Immunogen: | Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding S337 of human E2F1. | Gene Symbol: E2F1 Entrez: | 1869 (Human) | Omim: | 189971 (Human) | Swiss Prot: | NP_005216; Q01094 (Human) | Related Genes: | ARID4A, CDKN1A, CDKN2A, TP53, CDK2, E2F4, RB1, CDK4, E2F3, E2F2, CCND1, TCEAL1, D4S234E, RBL1, MYC, RBL2, TFDP1, CCNA2, PCNA, RAB3GAP1, NOLC1, E2F5, PAK3, DCTN6, SSSCA1, IFI27, PSMD9, MDM2, SLC12A9, CDKN1B, BCL2, DHFR, CDC2, CASP3, TP73, SP1, ARHGAP24, NOL3, BAX, DAND5 | Background: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. Species: Reactivity: | Human. Other species not tested. | Applications: Uses: | This antibody is useful for Western Blot (Cell lysate), Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). | Dilutions: | Western Blot,Immunohistochemistry-Paraffin | Packaging: Storage: | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. | Preservative: | 0.09% Sodium Azide | Limitations: | This product is for research use only and is not approved for use in humans or in clinical diagnosis. Products are guaranteed for 6 months from date of receipt, except for peptides and proteins which are guaranteed for 3 months. | |
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