|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-358522 |
AP07714PU-N |
NADE / BEX3//Human, Mouse/Rabbit |
1/EA |
|
|
|
 |
문의 |
|
|
|
|
|
|
|
Subject
|
NADE / BEX3 |
|
Description
|
/ Human, Mouse/Rabbit |
|
Clonality
|
Mono |
|
Company
|
Acris Antibodies GmbH |
|
Application
|
Paraffin Sections, Western blot / Immunoblot |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 50 ug | | Reactivity | Human, Mouse | | Presentation | Purified | | Applications | Paraffin Sections, Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Not USA/Canada | | Synonyms | NGFRAP1, DXS6984E | | Swiss Prot Num | Q00994 | | Immunogen | Synthetic Peptide corresponding to 14 Amino Acids near the middle of human NADE. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Dilute only prior to immediate use. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | |
| Format | State: Liquid purified IgG fraction. | | ? | Purification: Ion Exchange Chromatography. | | ? | Buffer System: Phosphate Buffered Saline PBS containing 0.02% Sodium Azide as preservative. | |
| Specificity | Species Human and Mouse. | | Application | Immunohistochemistry on Paraffin Sections (5 ?g/ml). Western Blot (0.5-2 ?g/ml). | | Background | The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR. Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed. Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells, NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage. | |
|
|
|
|
