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Cat. No |
Model |
Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-24-358525 |
AP07162PU-N |
NAK1//Human, Mouse/Rabbit |
1/EA |
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Subject
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NAK1 |
Description
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/ Human, Mouse/Rabbit |
Clonality
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Mono |
Company
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Acris Antibodies GmbH |
Application
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Immunofluorescence, Paraffin Sections, Western blot / Immunoblot |
Conjugation
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Immunogen
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Contents
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Description: Manufacturer | Acris Antibodies GmbH | Quantity | 50 ug | Reactivity | Human, Mouse | Presentation | Purified | Applications | Immunofluorescence, Paraffin Sections, Western blot / Immunoblot | Isotype | IgG | Host | Rabbit | PDF datasheet | view | Shipping to | Not USA/Canada | Synonyms | NR4A1, GFRP1, HMR, NUR77, ST-59, N10 | Swiss Prot Num | P22736 | Immunogen | Synthetic peptide | Product Type | Antibodies | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | |
Format | State: Liquid purified Ig | ? | Purification: Protein G column | ? | Buffer System: PBS containing 0.2% gelatin, 0.05% sodium azide. | |
Specificity | This antibody reacts to Nak1. A synthetic peptide corresponding to aa 251-266 of human Nak1. It will cross-react with mouse Nak1. | Application | Western Blot: 1:500 - 1:1000. Immunohistochemistry: 20 - 40 ?g/ml. ICC. | Background | Nak1 is a member of the steroid/thyroid hormone receptor superfamily. The gene for Nak-1 is induced rapidly by androgens/growth factors and may have functions related to cell proliferation, differentiation and apoptosis (1). Liu et al (2) have demonstrated that mouse nur77 is necessary for induced apoptosis in T-cell hybridomas and can also be induced during early mitogenesis. Nak1 is a phosphoprotein and its size ranges from 67 kD to 88 kD, depending on post-translational modifications. Nak1, a NR4 Nerve Growth Factor-Like receptor, has been shown to affect the hypothalamic-pituitary axis, neuronal differentiation, neuroendocrine regulation of adrenocortical function, and T-cell apoptosis. Nak1 also is known as nuclear receptor Tr3 and is similar to mouse Nur77 and rat NGFI-B. It is encoded by one of the immediate early genes (IEG) in response to nerve growth factor and other serum growth factors. Nak1 can bind to DNA as a monomer, homodimer, or heterodimer (with retinoid X receptors). Nak1 has been shown to inhibit vascular lesion formation and could serve as a novel target in the treatment of vascular diseases. | Concentration | 0.5 mg/ml | |
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