|
| |
| Cat. No |
Model |
Description |
Unit |
Price
(VAT별도) |
납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-372050 |
AP14563PU-N |
DAXX//Human/Rabbit |
1/EA |
|
|
|
 |
문의 |
|
|
|
|
|
|
|
Subject
|
DAXX |
|
Description
|
/ Human/Rabbit |
|
Clonality
|
Mono |
|
Company
|
Acris Antibodies GmbH |
|
Application
|
Enzyme Immunoassay, Paraffin Sections |
|
Conjugation
|
|
|
Immunogen
|
|
|
Contents
|
Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 mg | | Reactivity | Human | | Presentation | Aff - Purified | | Applications | Enzyme Immunoassay, Paraffin Sections | | Isotype | Ig | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | BING2, DAP6, hDaxx, ETS1-associated protein 1, EAP1 | | Swiss Prot Num | Q9UER7 | | Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S517 of human DAXX. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Cantrell, S.R., et al., J. Virol. 79(12):7792-7802 (2005). 2. Greger, J.G., et al., J. Virol. 79(8):4610-4618 (2005). 3. Chang, C.C., et al., J. Biol. Chem. 280(11):10164-10173 (2005). 4. Beausoleil, S.A., et al., Proc. Natl. Acad. Sci. U.S.A. 101(33):12130-12135 (2004). 5. Gostissa, M., et al., J. Biol. Chem. 279(46):48013-48023 (2004). | |
| Format | State: Liquid purified Ig | | ? | Purification: Protein A column, followed by peptide affinity purification | | ? | Buffer System: PBS with 0.09% (W/V) sodium azide | |
| Specificity | This antibody reacts to DAXX. | | Application | ELISA: 1/1,000. Immunohistochemistry: 1/10 - 1/50. | | Background | DAXX is a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, this protein functions as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with centromeres in G2 phase. In the cytoplasm, this protein may function to regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational modifications, including sumoylation, phosphorylation and polyubiquitination. | | Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. | | Concentration | 0.25 mg/ml | |
|
|
|
|
