| Synonyms | BING2, DAP6, hDaxx, ETS1-associated protein 1, EAP1 |
| Swiss Prot Num | Q9UER7 |
| Immunogen | Peptide corresponding to amino acids 722-740 at the C-terminus of human DAXX |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Yang, X. et al. (1997) Daxx, a novel Fasbinding protein that activates JNK and apoptosis. Cell 89: 1067 - 1076. 2. Kiriakidou, M. et al. (1997) Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. DNA Cell Biol. 16: 1289 - 1298. |
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| Format | State: Liquid purified IgG |
| ? | Buffer System: Phosphate buffered saline containing 0.02% Sodium Azide |
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| Specificity | This antibody recognises a novel Fas binding protein that has been designated DAXX. This antibody recognises a 120kD major band of DAXX protein in Western blotting of HeLa cell lysates. |
| Application | Western Blot: 1/500 - 1/1000; |
| Background | DAXX binds specifically to the death domain of Fas and enhances Fas induced apoptosis and activates the Jun N-terminal kinase (JNK) pathway. DAXX is widely expressed in both foetal and adult tissues. |
| Caution | (A full Health and Safety assessment is available upon request) This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only. |
| Concentration | 0.5 mg/ml |
