Synonyms | DAP kinase 3, ZIP-kinase, DLK |
Swiss Prot Num | O43293 |
Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human DAPK3. |
Product Type | Antibodies |
Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
References | 1. Endo, A., et al., J. Biol. Chem. 279(40):42055-42061 (2004). 2. Kawai, T., et al., Mol. Cell. Biol. 23(17):6174-6186 (2003). 3. Preuss, U., et al., Nucleic Acids Res. 31(3):878-885 (2003). 4. Page, G., et al., Oncogene 18(51):7265-7273 (1999). 5. Murata-Hori, M., et al., FEBS Lett. 451(1):81-84 (1999). |
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Format | State: Liquid purified Ig |
? | Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS |
? | Buffer System: PBS with 0.09% (W/V) sodium azide |
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Specificity | This antibody reacts to DAPK3. |
Application | ELISA: 1/1,000. |
Background | Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. DAPK3 fors a homodimer or heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. DAPK3 Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. This protein interacts with AATF and CDC5L. |
Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Concentration | 0.25 mg/ml |