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Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-368517 |
AP13715PU-N |
Activin receptor type 2B (ACVR2B)//Human/Rabbit |
1/EA |
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Subject
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Activin receptor type 2B (ACVR2B) |
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Description
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/ Human/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 mg | | Reactivity | Human | | Presentation | Purified | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Isotype | Ig | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | ACTR-IIB, ACTRIIB, Activin receptor type IIB | | Swiss Prot Num | Q13705 | | Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human ACVR2B. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Harrison, C.A., et al., J. Biol. Chem. 279(27):28036-28044 (2004). 2. Martins da Silva, S.J., et al., Dev. Biol. 266(2):334-345 (2004). 3. Casagrandi, D., et al., Mol. Hum. Reprod. 9(4):199-203 (2003). 4. Shin, B.K., et al., J. Biol. Chem. 278(9):7607-7616 (2003). 5. Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002). | |
| Format | State: Liquid purified Ig | | ? | Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS | | ? | Buffer System: PBS with 0.09% (W/V) sodium azide | |
| Specificity | This antibody reacts to Activin Receptor Type IIB (ACVR2B). | | Application | ELISA: 1/1,000. Western blotting: 1/100 - 1/500. | | Background | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. ACVR2B (activin A type IIB receptor)displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. | | Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. | | Concentration | 0.25 mg/ml | |
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