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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-368501 |
AP14607PU-N |
Activin receptor type 1 (ACRV1)//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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Activin receptor type 1 (ACRV1) |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 mg | | Reactivity | Human, Mouse | | Presentation | Purified | | Applications | Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot | | Isotype | Ig | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | Activin receptor type IA, ACVRLK2, ALK2, SKR1, ACRV1A | | Swiss Prot Num | Q04771 | | Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the center region of human ACVR1. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Mitu, Grace M., et al. Am J Physiol Renal Physiol 2007 Nov 01;293(5):F1641-1648. 2. Weber, Frank, et al. J. Clin. Endocrinol. Metab. 2006 Sep 01;91(9):3584-3591. (Applications: WB) | |
| Format | State: Liquid purified Ig | | ? | Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS | | ? | Buffer System: PBS with 0.09% (W/V) sodium azide | |
| Specificity | This antibody reacts to Activin Receptor Type IA (ACVR1). | | Application | ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. | | Background | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1 (activin A type I receptor) signals a particular transcriptional response in concert with activin type II receptors. | | Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. | | Concentration | 0.25 mg/ml | |
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