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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-368504 |
AP14596PU-N |
Activin receptor type 1B (ACVR1B)//Human, Mouse/Rabbit |
1/EA |
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문의 |
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Subject
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Activin receptor type 1B (ACVR1B) |
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Description
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/ Human, Mouse/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 mg | | Reactivity | Human, Mouse | | Presentation | Purified | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Isotype | Ig | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | ACTR-IB, ACVRLK4, ALK4, Activin receptor type IB, SKR2 | | Swiss Prot Num | P36896 | | Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR1B. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Harrison, C.A., et al., J. Biol. Chem. 278(23):21129-21135 (2003). 2. Mukasa, C., et al., Endocrinology 144(4):1603-1611 (2003). 3. Danila, D.C., et al., J. Clin. Endocrinol. Metab. 87(10):4741-4746 (2002). 4. Schneider-Kolsky, M.E., et al., Placenta 23(4):294-302 (2002). 5. Roijer, E., et al., Mamm. Genome 9(3):266-268 (1998). | |
| Format | State: Liquid purified Ig | | ? | Purification: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS | | ? | Buffer System: PBS with 0.09% (W/V) sodium azide | |
| Specificity | This antiobdy reacts to Activin A Receptor Type IB (ACVR1B). | | Application | ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Flow cytometry. | | Background | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The gene for ACVR1B (activin A type IB receptor) is composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. | | Concentration | 0.25 mg/ml | |
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