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Description |
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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-368510 |
AP13709PU-N |
Activin receptor type 1C (ACVR1C)//Human/Rabbit |
1/EA |
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Subject
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Activin receptor type 1C (ACVR1C) |
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Description
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/ Human/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 0.1 mg | | Reactivity | Human | | Presentation | Purified | | Applications | Enzyme Immunoassay, Paraffin Sections, Western blot / Immunoblot | | Isotype | Ig | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | ACTR-IC, ACTRIC, ALK7 | | Swiss Prot Num | Q8NER5 | | Immunogen | This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the N-terminal region of human ACVR1C. | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | | References | 1. Munir, S., et al., J. Biol. Chem. 279(30):31277-31286 (2004). 2. Kim, B.C., et al., J. Biol. Chem. 279(27):28458-28465 (2004). 3. Roberts, H.J., et al., Biol. Reprod. 68(5):1719-1726 (2003). 4. Tsuchida, K., et al., Mol. Cell. Endocrinol. 220 (1-2), 59-65 (2004). 5. Bondestam, J., et al., Cytogenet. Cell Genet. 95 (3-4), 157-162 (2001) | |
| Format | State: Liquid purified Ig | | ? | Purification: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS | | ? | Buffer System: PBS with 0.09% (W/V) sodium azide | |
| Specificity | This antibody reacts to Activin A Receptor Type IC (ACVR1C). | | Application | ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100. | | Background | ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis. | | Caution | This product is for research use only. Not for use in diagnostic or therapeutic procedures. | | Concentration | 0.25 mg/ml | |
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