| Synonyms | ADAMTS-4, ADAM-TS4, Aggrecanase-1, ADMP1, ADMP-1, KIAA0688 |
| Swiss Prot Num | O75173 |
| Immunogen | Synthetic peptide corresponding to C-terminal domain of human ADAMTS4 - KLH conjugated. |
| Product Type | Antibodies |
|
| Immunogen | Swiss Prot Num: O75173 |
| ? | Remarks: Rat Identity: 29% Rat Similarity: 41% |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
|
| Format | State: Liquid purified Ig fraction. |
| ? | Purification: Immunoaffinity Chromatography. |
| ? | Buffer System: PBS containing 0.09% Sodium Azide as preservative. |
|
| Specificity | This antibody reacts with C-terminal domain of ADAMTS4. |
| Application | Immunohistochemistry on Paraffin Embedded Tissues: 20 µg/ml. |
| Background | ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. |
| Concentration | 1.0 mg/ml |
