| Synonyms | TRAF3IP2, C6orf4, C6orf5, C6orf6, ACT1 |
| Swiss Prot Num | O43734 |
| Immunogen | Synthetic peptide |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C to -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
|
| Format | State: Liquid purified Ig |
| ? | Purification: Immunoaffinity Chromatography |
| ? | Buffer System: Phosphate buffered saline, containing 0.02% sodium azide |
|
| Specificity | This antibody reacts to a synthetic peptide (ppqlqetrmnrsip) corresponding to amino acids 2 to 15 of CIKS. |
| Application | Western BLot: 0,5 - 1 ?g/ml. Immunohistochemistry: 1 ?g/ml. |
| Background | Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB associates with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. IkB is phosphorylated by IkB kinase (IKK) complex that contains IKKa, IKKb, and IKKg. A novel molecule that associates with and activates IKK was recently identified and designated CIKS (for connection to IKK and SAPK/JNK) and Act1 (for NF-kB activator 1). CIKS directly interacts with IKKg. CIKS/Act1 also activates activating transcription factor (ATF) and activator protein 1 (AP-1) through Jun kinase (JNK). These results indicate that CIKS/Act1 is involved in the inflammation and stress responses. CIKS/Act1 is ubiquitously expressed in human tissues. |
