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Description |
Unit |
Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-24-368581 |
AP01506PU-N |
Adenylate cyclase type 4//Human, Mouse, Rat/Rabbit |
1/EA |
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문의 |
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Subject
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Adenylate cyclase type 4 |
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Description
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/ Human, Mouse, Rat/Rabbit |
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Clonality
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Mono |
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Company
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Acris Antibodies GmbH |
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Application
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Enzyme Immunoassay, Western blot / Immunoblot |
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Conjugation
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Immunogen
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Contents
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Description: | Manufacturer | Acris Antibodies GmbH | | Quantity | 100 ug | | Reactivity | Human, Mouse, Rat | | Presentation | Aff - Purified | | Applications | Enzyme Immunoassay, Western blot / Immunoblot | | Host | Rabbit | | PDF datasheet | view | | Shipping to | Worldwide | | Synonyms | Adenylate cyclase type IV,Adenylyl cyclase 4, ADCY4 | | Swiss Prot Num | Q8NFM4 | | Product Type | Antibodies | | Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. | |
| Format | State: Liquid purified Ig | | ? | Purification: Affinity chromatography | | ? | Buffer System: Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2. | |
| Specificity | A Cyclase IV antibody detects endogenous levels of A Cyclase IV protein. | | Application | ELISA: 1:20000~1:40000. WB: 1:500~1:1000. | | Background | Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to G?± s) for GTP, the dissociation of GTP-G?± s from G?²?³ and G?± s-mediated activation of adenylyl cyclase. Adenylyl cyclase IV (AC IV) and IX mRNA are expressed in all kidney nephron segments. AC IV exhibits moderate staining in type II and type IV fibrocytes in rat cochlea and immunoreactivity is also observed in type I fibrocytes. Activation of the D2 dopaminergic and m4 muscarine receptors inhibits the activity of adenylyl cyclase isozymes I, V, VI and VIII, whereas type II, IV and VII are stimulated and type III is not affected. | | Concentration | 1,0 mg/ml | |
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