| Catalog Number | GTX40054 |
| Product Name | ACE [501] antibody |
| Product Description | Mouse monoclonal [501] to Angiotensin Converting Enzyme |
| Synonyms | 24310 | Ace | Dcp1 | StsRR92 | |
| Background | ACE converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilatator. ACE exists in two forms, a 170KD somatic form and a 90KD germinal form. The somatic form is expressed by endothelial cells (especially those of lung capillaries and arterioles), epithelial cells (especially in proximal renal tubules and small intestine), by some neuronal cells and variably by some macrophages and T lymphocytes. The germinal form is expressed by spermatozoa. |
| Clonality | Monoclonal |
| Clone No | 501 |
| Host | Mouse |
| Isotype | IgM |
| Immunogen | Angiotensin Converting Enzyme purified from rat lung. |
| Antigen Species | Rat |
| Tested Applications | ELISA, Flow cytometry/FACS. The usefulness of this product in other applications has not been determined. |
| Application Note | ELISA: Use at an assay dependent dilution. FACS: Use at an assay dependent dilution for detection of ACE or ACE-positive cells. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Species Cross Reactivity | Cross-reacts with Human, Mouse and Cow ACE and ACE-positive endothelial cells. Not yet tested in other species. |
| Target | ACE |
| Cellular Localization | Type I membrane protein |
| Purification | Purified IgM |
| Purification Note | Precipitation with 6% polyethylene glycol (PEG). OD280nm. |
| Storage Buffer | Preservative: None. Constituents: PBS. pH 7.4 |
| Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
