| Catalog Number | GTX23455 |
| Product Name | Acrp30 antibody |
| Product Description | Rabbit polyclonal to Acrp30 |
| Synonyms | 11450 | Adipoq | 30kDa | Acdc | Acrp30 | GBP28 | adipo | apM1 | |
| Background | Adipose cells produce and secrete numerous physiologically important proteins, such as lipoprotein lipase (LPL), leptin, and Adipocyte complement related protein of 30 kDa (Acrp 30). Acrp 30 is a circulating protein that is secreted exclusively by differentiated adipocytes. During adipocyte differentiation, mRNA levels of Acrp 30 have been shown to be induced over 100-fold. Studies indicate that Acrp 30 enhances the ability of sub-physiological levels of insulin to suppress glucose production, thus linking adipose tissue to whole body glucose regulation. Acrp30 function appears to be regulated by phosphatidylinositol-3-kinase (PI3-K) since Acrp30 secretion is blocked by pharmacological inhibitors of this kinase. mRNA levels of Acrp 30 have been shown to be significantly reduced in adipose tissue of obese patients with Type 2 diabetes relative to control subjects. Structural similarities to TNFalpha suggests that Acrp 30 may play a role in pathogenesis of insulin resistance in Type 2 diabetes. Because Acrp 30 is down-regulated in various forms of obesity and its structural similarity to TNFalpha, it is currently being investigated as an important regulator of whole body energy homeostasis. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic Peptides: E(18)DDVTTTEELAPALV(32) and F(187)TYDQYQEKNVDQA(200).Immunizing peptides correspond to amino acid residues 18-32 and 187-200 from mouse Acrp 30 protein. |
| Antigen Species | Mouse |
| Tested Applications | Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | Western Blot: Use at an assay dependent dilution. Immunoprecipitation: assay dependent. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects an ~30 kDa protein representing Acrp 30 from mouse serum. |
| Specificity | Detects Acrp30 from mouse serum. |
| Species Cross Reactivity | Cross-reacts with Mouse and very weakly with Rat. Does not cross-react with Human. Not yet tested in other species.Please see the enquiries section of the online datasheet for further discussion. |
| Target | Acrp30 |
| Cellular Localization | Secreted |
| Form Supplied | Liquid |
| Purification | Protein A purified |
| Storage Buffer | PBS, 1 mg/ml BSA, 0.05% sodium azide |
| Storage Instruction | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
Image:img4103.jpgWestern blot of Acrp30 on mouse serum. Print:Print
