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Price
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납기 |
재고 |
DataSheet |
주문/견적 |
| LCA-25-386149 |
GTX13990 |
AKT antibody//Human,Mouse,rat,Xenopuslaevis,cow/Chicken |
1/EA |
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문의 |
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Subject
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AKT antibody |
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Description
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/ Human,Mouse,rat,Xenopuslaevis,cow/Chicken |
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Clonality
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Poly |
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Company
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GeneTex |
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Application
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Western Blot |
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Conjugation
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Immunogen
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Contents
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| Catalog Number | GTX13990 | | Product Name | AKT antibody | | Product Description | Chicken polyclonal to AKT | | Synonyms | 207 | AKT1 | 164730 | P31749 | MGC99656 | PKB | PRKBA | RAC | RAC-ALPHA | 208 | AKT2 | 125853 | P31751 | PKBBETA | PRKBB | RAC-BETA | | | Background | AKT (Protein Kinase B, PKB) was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of Akt has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI 3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus. AKT has two main roles: (i) inhibition of apoptosis; (ii) promotion of proliferation. | | Clonality | Polyclonal | | Host | Chicken | | Isotype | IgY | | Immunogen | Recombinant fragment: SDVAIVKEG WLHKRGEYIK TWRPRYFLLK NDGTFIGYKE RPQDVDQREA PLNNFSVAQC QLMKTERPRP NTFIIRCLQW TTVIERTFHV ETPEEREEWT TAIQTVADGL KKQEEEEMDF RSGSPSDNSG AEEMEVSLAK PKHRVTMNEF EYLKLLGKGT FGKVILVKEK ATGRYYAMKI LKKEVIVAKD EVAHTLTENR, corresponding to amino acids 2-200 of Human AKT. | | Antigen Species | Human | | Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. | | Application Note | For WB: Use at an assay dependent dilution. Predicted molecular weight: 58 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. | | Species Cross Reactivity | Human, mouse, rat, Xenopus laevis and cow - Not tested in other species | | Target | AKT | | Cellular Localization | Cytoplasmic and Nuclear after activation by integrin linked protein kinase 1 (ILK1). | | Form Supplied | Liquid | | Purification | Affinity purified with antigen | | Storage Buffer | PBS, no preservatives added | | Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. | Image:img24501.jpgWestern Blot: GTX13990 dilution: 1:2,000. Goat anti-13990-HRP dilution: 1:1,000. E coli-derived fusion protein as test antigen. Print:Print |
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