| Catalog Number | GTX11927 |
| Product Name | D4 GDI [97A1015] antibody |
| Product Description | Mouse monoclonal [97A1015] to D4 GDI |
| Synonyms | 397 | ARHGDIB | 602843 | P52566 | D4 | GDIA2 | GDID4 | LYGDI | Ly-GDI | RAP1GN1 | |
| Background | D4 GDI belongs to the family of Rho GDIs or GDP dissociation inhibitors for the Rho/Rac family of small G proteins; consisting of RhoGDI 1, D4 GDI/RhoGDI2 and Rho GDI3. It inhibits the release of GDP from the Rho proteins, essential for GTP loading and activation of GTPase activity. D4 GDI is located in the cytoplasm and in involved in the regulation of the membrane association and dissociation cycle of Rho/Rac proteins. It is known to be a substrate for caspase 3 during Fas mediated apoptosis. |
| Clonality | Monoclonal |
| Clone No | 97A1015 |
| Host | Mouse |
| Isotype | IgG1 |
| Immunogen | Synthetic peptide corresponding to amino acid residue(s) in the Fas-induced cleavage site of human D4-GDI. |
| Antigen Species | Human |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | WB: Use at a concentration of 1 - 2 μg/ml. Detects a band of approximately 23 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | HL60 cells treated with 10 ng/ml of an anti-Fas mAb |
| Target | D4 GDI |
| Cellular Localization | Cytoplasmic and Nuclear |
| Purification | Protein G affinity purified |
| Storage Buffer | PBS, containing 0.05% BSA and 0.05% sodium azide |
| Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
