| Catalog Number | GTX22499 |
| Product Name | alpha T Catenin [892_24D2S] antibody |
| Product Description | Mouse monoclonal [892_24D2S] to alpha T Catenin |
| Synonyms | 29119 | CTNNA3 | 607667 | Q9UI47 | MGC26194 | MGC75041 | VR22 | |
| Background | Catenins are proteins that connect cadherin/b-catenin cell adhesion complexes to the actin cytoskeleton. Although originally discovered in testis, alpha T catenin is expressed in other tissues, the highest levels being observed in heart. Immunohistochemical analysis showed human alpha T catenin localization at intercalated discs of cardiomyocytes and in peritubular myoid cells of testis. It is proven that alpha T catenin can functionally restore cell-cell adhesion in colon cancer cells lacking a-catenins. This indicates that this protein is involved in the formation of specific cell-cell contacts in specific types of muscle cells. The encoded protein has about the same predicted size (100 kDa) as other a-catenins to which it shows an overall amino acid identity of 57%. In cells transfected with a T-catenin cDNA, interaction with b-catenin was demonstrated by co-immunoprecipitation. |
| Clonality | Monoclonal |
| Clone No | 892_24D2S |
| Host | Mouse |
| Isotype | IgG2a |
| Immunogen | A synthetic peptide corresponding to amino acids 164-177 of the human alpha T catenin protein including an additional N-terminal cysteine (CVANKSDLQKTYQKL) coupled to keyhole limpet hemocyanin. |
| Antigen Species | Human |
| Tested Applications | Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | For ICC: Use at an assay dependent dilution. For IF: |
| Specificity | Does not show any cross reaction with alpha E-catenin or alpha N-catenin in western blot analysis. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Target | alpha T Catenin |
| Form Supplied | Liquid |
| Purification | Protein A affinity purified. |
| Storage Buffer | Preservative: 0.09% Sodium Azide; Constituents: PBS |
| Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
