Catalog Number | GTX101781 |
Product Name | macroH2A.1 antibody |
Full Name | H2A histone family, member Y |
Product Description | Rabbit polyclonal antibody to macroH2A.1 (H2A histone family, member Y) |
Synonyms | H2A.y | H2A/y | H2AF12M | H2AFJ | MACROH2A1.1 | mH2A1 | macroH2A1.2 |
Background | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq] |
Clonality | Polyclonal |
Host | Rabbit |
Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 167 of Human macroH2A.1 |
Antigen Species | Human |
Tested Applications | Dot Blot |
Application Note | Further validation in progress. |
Specificity | This antibody is specific to the Protein antigen from macroH2A.1 . |
Species Cross Reactivity | Human - Not yet tested in other species |
Positive Controls | Target recombinant protein |
Target | macroH2A.1 |
Predicted Target Size(KDa) | 39.49 |
Cellular Localization | Nucleus |
Form Supplied | Liquid |
Concentration | 6.71 mg/ml |
Purification | Affinity purified by Protein A. |
Storage Buffer | 1XPBS, 1%BSA, 20% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
Storage Instruction | Keep as concentrated solution. Aliquot and store at -20¨¬C or below. Avoid multiple freeze-thaw cycles. |
Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |