| Catalog Number | GTX108370 |
| Product Name | P Glycoprotein antibody |
| Full Name | ATP-binding cassette, sub-family B (MDR/TAP), member 1 |
| Product Description | Rabbit polyclonal antibody to P Glycoprotein (ATP-binding cassette, sub-family B (MDR/TAP), member 1) |
| Synonyms | ABC20 | CD243 | CLCS | GP170 | MDR1 | MGC163296 | P-gp | PGY1 |
| Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Synthetic peptide contain a sequence corresponding to a region within amino acids 1217 and 1280 of Human P Glycoprotein |
| Antigen Species | Human |
| Tested Applications | Dot Blot |
| Application Note | Further validation in progress. |
| Specificity | This antibody is specific to the peptide antigen from P Glycoprotein . |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Synthetic peptide: 1:8,000 |
| Target | P Glycoprotein |
| Predicted Target Size(KDa) | 141.5 |
| Cellular Localization | Membrane; Multi-pass membrane protein |
| Form Supplied | Liquid |
| Concentration | 1 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
