| Catalog Number | GTX70204 |
| Product Name | Jab1 [2A10.8] antibody |
| Product Description | Mouse monoclonal antibody to human Jab1 |
| Synonyms | Jab 1, Jab-1 |
| Background | JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the ""Signalosome"", which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome. |
| Clonality | Monoclonal |
| Clone No | 2A10.8 |
| Host | Mouse |
| Isotype | IgG2b |
| Immunogen | The full-length mouse JAB-1 gene expressed in E. coli. |
| Antigen Species | Mouse |
| Tested Applications | Immunofluorescence, Immunohistochemistry, Immunoprecipitation. The usefulness of this product in other applications has not been determined. |
| Application Note | For IP: Use at a concentration of 0.5 - 1 ?g/ml. For WB: Use at a dilution of 1:1,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. |
| Species Cross Reactivity | Human and Mouse - Not yet tested in other species |
| Positive Controls | 293 cell lysate |
| Target | Jab1 |
| Cellular Localization | Nuclear/Cytoplasmic |
| Form Supplied | Liquid |
| Purification | Protein G Affinity Purified |
| Purification Note | From hybridoma tissue culture supernatant |
| Storage Buffer | Phosphate-buffered saline, pH 7.4, containing no preservatives |
| Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
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