Catalog Number | GTX97047 |
Product Name | JAK1 antibody |
Product Description | Mouse polyclonal to JAK1 |
Synonyms | JAK1A, JAK1B |
Background | Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. |
Clonality | Polyclonal |
Host | Mouse |
Immunogen | JAK1 (NP_002218, 221 a.a. ~ 320 a.a) partial recombinant protein with GST tag. |
Antigen Species | Human |
Tested Applications | ELISA. The usefulness of this product in other applications has not been determined. |
Application Note | For ELISA (tested with immunogen): Use at an assay dependednt dilution. For WB: (tested against immunogen): Use at an assay dependednt dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. |
Specificity | Not tested |
Species Cross Reactivity | Human - Not yet tested in other species |
Positive Controls | Recombinant protein |
Target | JAK1 |
Form Supplied | Liquid |
Purification | Unpurified |
Purification Note | From polyclonal serum |
Storage Buffer | Antiserum containing 50% glycerol |
Storage Instruction | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20¨¬C or below. Avoid freeze-thaw cycles. |
Notes | Antibody reactive against recombinant protein with GST tag on ELISA. Please enquire about availability of recombinant protein. |
Manufacturer & Mfg Part# | Abnova H00003716-A01Only available to US end-users. Not available outside of the US or for resale inside of the US. |