| Catalog Number | GTX82390 |
| Product Name | X box-binding protein 1 antibody |
| Product Description | Chicken polyclonal to X box-binding protein 1 |
| Background | Transcription factor essential for hepatocyte growth. the differentiation of plasma cells. the immunoglobulin secretion. and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5-GATGACGTG[TG]N(3)[AT]T-3. and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the tax-responsive element (TRE) of HTLV-I. This protein is a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. The protein contains two domains commonly found in transcription factors that confer DNA binding and dimerization capability. This protein product was also separately identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. There is also a recent finding that the same agents that cause an ER stress response. the unfolded protein response. also increase transcription of this gene. This increase in transcription requires an ER stress response consensus binding element in the promoter. Adding to the list of functional possibilities is a recent report from studies of knockout mice showing that this gene is essential for hepatocyte growth. A pseudogene has been identified and localized to chromosome 5. |
| Clonality | Polyclonal |
| Host | Chicken |
| Isotype | IgY |
| Immunogen | Synthetic peptide - human X box-binding protein 1 |
| Antigen Species | Human |
| Tested Applications | Western Blot. The usefulness of this product in other applications has not been determined. |
| Application Note | WB (only tested on fusion protein): Use at a dilution of 1:2000. Colorimetric method for signal development. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | See Application Note |
| Target | X box-binding protein 1 |
| Form Supplied | Liquid |
| Purification | Affinity purified with antigen |
| Purification Note | From polyclonal serum |
| Storage Buffer | Phosphate-Buffered Saline containing no preservatives |
| Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
