| Catalog Number | GTX103200 |
| Product Name | TAB1 antibody |
| Full Name | mitogen-activated protein kinase kinase kinase 7 interacting protein 1 |
| Product Description | Rabbit polyclonal antibody to TAB1 (mitogen-activated protein kinase kinase kinase 7 interacting protein 1) |
| Synonyms | 3-Tab1 | MGC57664 | TAB1 |
| Background | The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 258 of Human TAB1 |
| Antigen Species | Human |
| Tested Applications | WB. The usefulness of this product in other applications has not been determined. |
| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Specificity | This antibody is specific to the Human TAB1 protein. |
| Species Cross Reactivity | Tested with Human antigen. Other species have not been tested. |
| Positive Controls | 293T |
| Target | TAB1 |
| Predicted Target Size(KDa) | 54.66 |
| Form Supplied | Liquid |
| Concentration | 0.26 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
Image:GTX103200 WB ImageWestern Blot analysis of MAP3K7IP1 expression in transfected 293T cell line by MAP3K7IP1 polyclonal antibody. A: Non-transfected lysate. B: MAP3K7IP1 transfected lysate. 12% SDS PAGEGTX103200 diluted at 1:500Print:Print
