| Catalog Number | GTX41083 |
| Product Name | 53BP1 antibody |
| Product Description | Rabbit polyclonal to 53BP1 |
| Background | p53 binding protein 1 (53BP1) plays a critical role in tumor suppression and is a putative substrate of ATM kinase. Upon DNA damage, it is phosphorylated and re-localizes to the presumptive sites of damage, specifically, double-strand breaks. This also suggests a role in DNA repair, maintaining genomic stability. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic peptide corresponding to the carboxy-terminus of h53BP1, conjugated to a carrier protein. |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | WB: Use at an assay dependent dilution. Detects a band of approximately >250 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Specificity | Recognises 53BP1 |
| Species Cross Reactivity | Cross-reacts with Human. Not yet tested in other species. |
| Positive Controls | HeLa whole cell lysate |
| Target | 53BP1 |
| Cellular Localization | Nuclear |
| Purification | Immunogen affinity purified |
| Storage Buffer | Preservative: None. Constituents: PBS. pH 7.2 |
| Storage Instruction | Store at 4°C. Aliquot and store at -20°C long-term. |
