| Catalog Number | GTX77940 |
| Product Name | 5-HT2C Receptor Antibody |
| Product Description | Rabbit polyclonal to 5-HT2C Receptor |
| Synonyms | GPCR Serotonin |
| Background | 5-HT2C, a Serotonin Receptor previously termed 5-HT1C, activates phospholipase C, resulting in a transient increase in intracellular calcium and activation of protein kinase C. Mutant mice lacking functional 5-HT2C receptor are overweight due to abnormal feeding behavior and are prone to epileptic seizures. Therefore, agonists of the 5-HT2C receptor such as m-chlorophenylpiperazine (mCPP) may be potential drugs for the treatment of obesity. However, mCPP also has unpleasant side effects such as anxiety and nausea in humans. Most psychedelic drugs bind 5-HT2A and 5-HT2C receptors, and their hallucinogenicity correlates with binding affinity. Expression of the 5-HT2C receptor has been reported predominantly in brain, but also in spinal cord and lung. ESTs have been isolated from human, mouse, and rat brain libraries. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic peptide - KLH conjugated. Peptide sequence identity/similarity to Mouse: 55/65%. Rat: 60/70%. |
| Antigen Species | Mouse |
| Tested Applications | Immunohistochemistry. The usefulness of this product in other applications has not been determined. |
| Species Cross Reactivity | Human. Others not determined. |
| Target | 5-HT2C Receptor |
| Form Supplied | Liquid |
| Purification | Peptide immunogen affinity column |
| Storage Buffer | Phosphate buffered saline, pH 7.7, containing 0.01% sodium azide |
| Storage Instruction | Long term: -70 °C; Short term: -4 °C |
