| Catalog Number | GTX71886 |
| Product Name | A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif, 5 (ADAMTS5) Antibody |
| Product Description | Rabbit Polyclonal to Human A Disintegrin - like and Metalloprotease with Thrombospondin Type 1 Motif 5 ( ADAMTS5 ) |
| Background | ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a met turn, a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic peptide - KLH conjugated |
| Tested Applications | IHC (Formalin-fixed paraffin-embedded sections). The usefulness of this product in other applications has not been determined. |
| Application Note | Immunohistochemistry with formalin fixed paraffin embedded tissues. Not tested for other uses. IHC-P: Use at a dilution of 1/100 - 1/200. |
| Species Cross Reactivity | Human. Others not determined. |
| Target | A Disintegrin-like and Metalloprotease with Thrombospondin Type 1 Motif, 5 (ADAMTS5) |
| Form Supplied | Liquid |
| Purification | Immunogen affinity purified. |
| Purification Note | Peptide immunogen affinity column |
| Storage Buffer | Phosphate buffered saline, PH 7.7 containing 0.01% sodium azide |
| Storage Instruction | Store at 4 °C short term; For long term storage aliquot and store at -20 °C or below. |
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