| Catalog Number | GTX30229 |
| Product Name | ABCA1 Antibody |
| Product Description | Rabbit polyclonal to ABCA1 |
| Synonyms | ABC 1, ABC Transporter 1, ABCA1, ATP-binding Cassette 1, ATP-binding Cassette Transporter 1, CERP, Cholesterol Efflux Regulatory Protein, |
| Background | Mutations in the ABCA1 gene (ATP-binding cassette transporter 1) have been reported in Tangier disease (TD). TD is an autosomal recessive disorder characterized by an absence of plasma HDL, cholesterol ester depositing in the reticulo-endothelial system and deviations in cellular lipid trafficking. ABCA1 mediates the apo-A1 associated export of cholesterol and phospholipids from the cell. It is expressed on the plasma membrane and the Golgi complex, and is regulated by cholesterol flux. Regulation of the cholesterol flux between HDL and macrophages is competitive between ABCA1 and SR-BI. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Partial peptide sequence (peptide used resides somewhere between a.a 1100-1300) of the human ABCA1 gene. Actual immunogen sequence is proprietary information. |
| Antigen Species | Human |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Specificity | This antibody is specific for ABCA1. |
| Species Cross Reactivity | Reacts with human and mouse ABCA1. Other species have not been tested. |
| Target | ABCA1 |
| Form Supplied | Liquid |
| Purification | affinity purified |
| Storage Buffer | serum with 0.02% sodium azide |
| Storage Instruction | Store at -20 °C. Avoid repeated freeze-thaws. |
| Notes | It is important not to boil the sample before loading onto a gel. Boiling can cause aggregation in large proteins, resulting in the proteins inability to enter the gel." |
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