| Catalog Number | GTX30777 |
| Product Name | ABL2 [1H1B11] antibody |
| Product Description | Mouse monoclonal [1H1B11] to ABL2 |
| Synonyms | Abelson murine leukemia viral oncogene homolog 2 | Abelson related gene protein | Tyrosine kinase ARG | ABLL | ARG | Tyrosine protein kinase ABL2 | v abl Abelson murine leukemia viral oncogene homolog 2 |
| Background | ABL2 (or ARG) is a nonreceptor cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of ABL1 and ABL2 includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and tumor cells. It is involved in translocation with the ETV6 gene in human leukemia and has an altered expression in several human carcinomas. Two isoforms of ABL2 with different N-termini (1A and 1B) have been identified. The C-terminal domain of ABL2 contains two F-actin-binding sequences that perform a number of actions related to cell morphology and motility by interacting with actin filaments. |
| Clonality | Monoclonal |
| Host | Mouse |
| Isotype | IgG1 |
| Immunogen | Ni-NTA purified truncated recombinant ABL2 expressed in E. Coli strain BL21 (DE3) |
| Tested Applications | ELISA, Immunofluorescence, Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | For ELISA: Use at a dilution of 1:10,000. For IF: Use at a dilution of 1:100-1:500. For WB: Use at a dilution of 1:200-1:1,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Target | ABL2 |
| Form Supplied | Liquid |
| Purification | Unpurified |
| Storage Buffer | Ascitic fluid containing 0.03% sodium azide |
| Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
