| Catalog Number | GTX15350 |
| Product Name | ACE2 antibody |
| Product Description | Rabbit polyclonal to ACE2 |
| Synonyms | 59272 | ACE2 | 300335 | Q9BYF1 | ACEH | DKFZP434A014 | |
| Background | Angiotensin converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function. ACE1 inhibitors such as catopril and lisinopril do not block ACE2 activity. ACE2 is restricted to the testis, heart, kidney and colon. The full length sequence for ACE2 encodes an 805 amino acid protein with predicted mass of 92.46 kDa and a pI of 5.22. No cross reactivity to ACE1. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic peptide corresponding to N terminal amino acids 2-18 of human ACE2. |
| Antigen Species | Human |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | WB: Use at a concentration of 0.5 - 2 μg/ml. Detects a band of approximately 90 kDa (predicted molecular weight: 97 kDa). Peptide available as GTX15353. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Human kidney or human testis cell lysate |
| Target | ACE2 |
| Cellular Localization | Nuclear |
| Form Supplied | Liquid |
| Purification | Affinity purified with antigen |
| Purification Note | From polyclonal serum |
| Storage Buffer | Phosphate-buffered saline, pH 7.2, containing 0.02% sodium azide |
| Storage Instruction | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
| Notes | Dissociation constant not determined. Peptide available as GTX15353. |
Image:img25478.gifWestern blot analysis of ACE2 in human kidney lysate with GTX15350 at 1 g/ml. Print:Print
