| Catalog Number | GTX21144 |
| Product Name | Acinus antibody |
| Product Description | Rabbit polyclonal to Acinus |
| Background | Chromatin condensation and nuclear fragmentation (CCNF)is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS. |
| Clonality | polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | C-terminal synthetic peptide. |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | WB: Use at a dilution of 1/500 - 1/1000. Detects a band of approximately 95 kDa (predicted molecular weight: 151 kDa before cleavage). Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Specificity | This antibody recognises the long form of the Acinus protein. |
| Species Cross Reactivity | Cross-reacts with Human. Not yet tested in other species. |
| Target | Acinus |
| Cellular Localization | Nuclear |
| Form Supplied | Liquid |
| Purification | IgG fraction |
| Storage Buffer | PBS with 0.02% sodium azide |
| Storage Instruction | Store at +2-8 °C for 3 months or -20 °C for longer periods. Avoid repeated freeze-thaw cycles. |
