| Catalog Number | GTX23183 |
| Product Name | Activin Receptor type II antibody [149/1] |
| Product Description | Mouse monoclonal [149 / 1] to Activin Receptor type II |
| Background | The activins and inhibins are glycoproteins that belong to the transforming growth factor beta like (TGF-b-like) superfamily of growth factors. These factors transduce their signals by interacting with two types of receptor serine / threonine kinases that phosphorylate members of the SMAD family of transcription factors, thereby promoting their nuclear localization. SMAD2 and 3 can form a complex with the activin receptor in a ligand-dependent manner. This complex formation is rapid but also transient. Indeed, soon after their association with the activin receptor, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. |
| Clonality | Monoclonal |
| Clone No | 149/1 |
| Host | Mouse |
| Isotype | IgG1 |
| Immunogen | Recombinant human type-2 activin receptor tyrosine kinase domain. |
| Antigen Species | Human |
| Tested Applications | Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | Immunoprecipitation (denatured): use at a concentration of 2?g / mg. Western Blotting: use at a concentration of 1?g / ml for 2hrs at RT. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects a band of 70 kDa, which corresponds to the predicted molecular weight of Activin receptor. |
| Specificity | Useful in the study of activin signal transduction pathways. |
| Species Cross Reactivity | Cross-reacts with Human. Not yet tested in other species. |
| Positive Controls | LS174T cells. |
| Target | Activin Receptor type II |
| Cellular Localization | Cell membrane and cytoplasmic. |
| Form Supplied | Liquid |
| Purification | Protein G purified |
| Storage Buffer | 10mM PBS, pH7.4, 0.2%BSA, 0.09% sodium azide |
| Storage Instruction | Keep as concentrated solution, aliquot and store at 4°C. Do not freeze. |
