| Catalog Number | GTX96189 |
| Product Name | ACTN4 antibody |
| Product Description | Mouse polyclonal to ACTN4 |
| Synonyms | FSGS, FSGS1 |
| Background | Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. |
| Clonality | Polyclonal |
| Host | Mouse |
| Immunogen | ACTN4 (NP_004915, 592 a.a. ~ 702 a.a) partial recombinant protein with GST tag. |
| Antigen Species | Human |
| Tested Applications | ELISA. The usefulness of this product in other applications has not been determined. |
| Application Note | For ELISA (tested with immunogen): Use at an assay dependednt dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. |
| Specificity | Not tested |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | Recombinant protein |
| Target | ACTN4 |
| Form Supplied | Liquid |
| Purification | Unpurified |
| Purification Note | From polyclonal serum |
| Storage Buffer | Antiserum containing 50% glycerol |
| Storage Instruction | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
| Notes | Antibody reactive against recombinant protein with GST tag on ELISA. Please enquire about availability of recombinant protein. |
| Manufacturer & Mfg Part# | Abnova H00000081-A01Only available to US end-users. Not available outside of the US or for resale inside of the US. |
