| Catalog Number | GTX11554 |
| Product Name | ADAM33 antibody |
| Product Description | Rabbit polyclonal to ADAM33 |
| Synonyms | 80332 | ADAM33 | 607114 | Q9BZ11 | DJ964F7.1 | DKFZp434K0521 | FLJ35308 | FLJ36751 | MGC71889 | |
| Background | ADAM33, also known as A disintegrin and metalloproteinase 33, is a member of the metalloproteinase family containing disintegrin-like domains (ADAMs). Human and mouse ADAM33 share approximately 70% sequence identity and 44% identity with Xenopus ADAM13 (thought to be a species orthologue). ADAM33 appears to be widely expressed and found in most organs. ADAM33 may act as a cell-attachment molecule, by binding integrins through the cysteine-rich domain. Recent work suggests that mutations in ADAM33 may be linked to asthma and that many of the mutations generate new cysteine residues, which may disturb the function of ADAM33. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic peptide corresponding to the cytoplasmic domain (Human). |
| Antigen Species | Human |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | WB: Use at a dilution of 1/1000. This dilutionis recommended using an alkaline phosphatase conjugated secondary antibody and BCIP/NBT as the substrate. A starting antibody dilution of 1/5000 is recommended for chemiluminescent substrates. Against the reduced protein, the antibody recognizes bands at 99 kDa (minor band), 58 kDa (major band), and cleaved products in cell lysates. Higher antibody dilutions may be necessary for non-human samples. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Target | ADAM33 |
| Cellular Localization | Type I membrane protein. |
| Purification | Immunogen affinity purified |
| Storage Buffer | Preservative: 0.05% Sodium Azide; Constituents: PBS with 50% Glycerol |
| Notes | Do not store below −22 ?C. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use." |
