Catalog Number | GTX99149 |
Product Name | NAGPA antibody |
Product Description | Mouse polyclonal to NAGPA |
Synonyms | APAA, UCE |
Background | Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as uncovering enzyme or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the proteins C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. |
Clonality | Polyclonal |
Host | Mouse |
Immunogen | NAGPA (NP_057340, 309 a.a. ~ 409 a.a) partial recombinant protein with GST tag. |
Antigen Species | Human |
Tested Applications | ELISA, Western blot. The usefulness of this product in other applications has not been determined. |
Application Note | For ELISA (tested with immunogen): Use at an assay dependednt dilution. For WB: (tested against immunogen): Use at an assay dependednt dilution. Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. |
Specificity | Not tested |
Species Cross Reactivity | Human - Not yet tested in other species |
Positive Controls | Recombinant protein |
Target | NAGPA |
Form Supplied | Liquid |
Purification | Unpurified |
Purification Note | From polyclonal serum |
Storage Buffer | Antiserum containing 50% glycerol |
Storage Instruction | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20¨¬C or below. Avoid freeze-thaw cycles. |
Notes | Antibody reactive against recombinant protein with GST tag on ELISA. Please enquire about availability of recombinant protein. |
Manufacturer & Mfg Part# | Abnova H00051172-A01Only available to US end-users. Not available outside of the US or for resale inside of the US. |