| Catalog Number | GTX108827 |
| Product Name | ACTR-I antibody |
| Full Name | activin A receptor, type I |
| Product Description | Rabbit polyclonal antibody to ACTR-I (activin A receptor, type I) |
| Synonyms | ACTRI | ACVR1A | ACVRLK2 | ALK2 | FOP | SKR1 | TSRI |
| Background | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 125 and 505 of ACTR-I |
| Antigen Species | human |
| Tested Applications | WB and IHC-P. The usefulness of this product in other applications has not been determined. |
| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000,IHC-P: 1:100-1:500. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Specificity | This antibody is specific to the human ACTR-I protein. |
| Species Cross Reactivity | human - Not yet tested in other species |
| Positive Controls | A431 | HeLa | HepG2 | Raji |
| Target | ACTR-I |
| Predicted Target Size(KDa) | 57.16 |
| Cellular Localization | Membrane |
| Form Supplied | Liquid |
| Concentration | 0.41 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
Image:GTX108827 WB ImageSample (30 ug of whole cell lysate) A: Hep G2 (GTX27900) 7.5% SDS PAGE GTX108827 diluted at 1:1000 GTX108827 IHC ImageImmunohistochemical analysis of paraffin-embedded CA922 xenograft, using ACTR-I (GTX108827) antibody at 1:100 dilution.Print:Print
