| Catalog Number | GTX13705 |
| Product Name | MA2 antibody |
| Product Description | Rabbit polyclonal to MA2 |
| Synonyms | 10687 | PNMA2 | 603970 | Q9UL42 | KIAA0883 | MA2 | MM2 | RGAG2 | |
| Background | In patients with cancer, symptoms of limbic and brain-stem dysfunction may result from a para-neoplastic disorder. Two proteins, Ma1 and Ma2, were discovered by presence of autoantibodies against them. Antibodies to Ma1 and Ma2 proteins identify a paraneoplastic disorder that affects the limbic system, brain stem, and cerebellum. These autoantibodies were used to clone Ma2, which codes for a protein (Ma2) that was recognized by serum from the 10 patients, but not by serum from 344 control subjects. Ma2 was selectively expressed by normal brain tissue and by the testicular tumors of the patients. Ma2 shares homology with Ma1, a ""brain-testis-cancer"" gene related to other para-neoplastic syndromes and tumors. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic peptide: AHLLGQAMAHAPQPLL, corresponding to amino acids 143-158 of Human MA2. |
| Antigen Species | Human |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | WB: Use at a dilution of 1/500 - 1/1000. Predicted molecular weight: 44 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | SK-N-SH cell lysate |
| Target | MA2 |
| Cellular Localization | Nuclear |
| Purification | Protein G purified |
| Storage Buffer | Preservative: 0.02% Sodium Azide; Constituents: PBS, 0.1mg/ml BSA. |
| Storage Instruction | Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
