| Catalog Number | GTX23337 |
| Product Name | Rab3D antibody |
| Product Description | Rabbit polyclonal to Rab3D |
| Synonyms | 19340 | Rab3d | C130057E11Rik | |
| Background | Rab proteins are low-molecular-weight GTP-binding proteins that form the largest branch of the Ras superfamily of GTPases. Located on the cytoplasmic face of organelles and vesicles, rab proteins are involved in intracellular membrane fusion reactions. Three membrane proteins, synaptosomal associated protein of 25 kDa (SNAP-25), synaptobrevin, and syntaxin, form the core of a ubiquitous membrane fusion machine that interacts with the soluble proteins N-ethylmaleimide-sensitive factor (NSF) and a-SNAP. Rab proteins, in coordination with the core fusion machinery and Munc-18, help to mediate vesicle docking and fusion. There exist over 40 rab proteins that have been described in mammals. Rab 3D has been shown to be present, in part, in the tongue, pancreas, and liver. |
| Clonality | Polyclonal |
| Host | Rabbit |
| Isotype | IgG |
| Immunogen | Synthetic Peptide: M(1)ASASEPPASPRDAADQN(18). Immunizing peptide corresponds to amino acid residues 1-18 from rat rab 3D protein. This sequence is completely conserved between the rat and mouse. |
| Antigen Species | Mouse |
| Tested Applications | Western blot. The usefulness of this product in other applications has not been determined. |
| Application Note | Western Blot: use at a concentration of 2.0 μg/ml. Not tested in other applications. Optimal dilutions / concentrations should be determined by the end user. By Western blot, this antibody detects an ~29 kDa protein representing recombinant mouse Rab 3D. |
| Specificity | Detects recombinant mouse rab 3D. This antibody does not detect rab 3A, 3B, or 3C. |
| Species Cross Reactivity | Cross-reacts with Mouse. Not yet tested in other species. |
| Target | Rab3D |
| Form Supplied | Liquid |
| Purification | Protein A purified |
| Storage Buffer | PBS, 1 mg/ml BSA, 0.05% sodium azide |
| Storage Instruction | Upon receipt - Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles. |
