Catalog Number | GTX10546 |
Product Name | p19 Skp1 antibody |
Product Description | Rabbit polyclonal to p19 Skp1 |
Synonyms | cyclin A/CDK2-associated p19 EMC19 OCP-II OCP2 organ of Corti protein 2 p19A p19skp1 RNA polymerase II elongation factor-like protein OCP2 SIII TCEB1L Transcription Elongation Factor B 1-like |
Background | Skp1 is an F-box protein which functions as a substrate recognition component of the SCF ubiquitin ligase complex. It binds to cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin proteolysis through an F-box motif. It is also involved in the control of beta-catenin levels the activity of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. |
Clonality | polyclonal |
Host | Rabbit |
Isotype | IgG |
Immunogen | Synthetic peptide - corresponding to amino acids 152- 163 of Human Skp1 |
Antigen Species | Human |
Tested Applications | Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined. |
Application Note | For IP : Use at an assay dependent dilution. For WB: Use at a dilution of 1;500-1:1,000. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user. |
Specificity | Reacts with human SKP1 |
Species Cross Reactivity | Human - Expected to cross-react with Mouse - Not yet tested in other species |
Target | Skp1 |
Form Supplied | Liquid |
Purification | Unpurified |
Storage Buffer | Whole antiserum containing 0.01% sodium azide |
Storage Instruction | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20¨¬C or below. Avoid freeze-thaw cycles. |