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Cat. No |
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Description |
Unit |
Price (VATº°µµ) |
³³±â |
Àç°í |
DataSheet |
ÁÖ¹®/°ßÀû |
LCA-25-390855 |
GTX18014 |
VAMP2 antibody//Human,Mouse,rat,Xenopuslaevis,cow,Guineapig/Rabbit |
1/EA |
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Subject
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VAMP2 antibody |
Description
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/ Human,Mouse,rat,Xenopuslaevis,cow,Guineapig/Rabbit |
Clonality
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Poly |
Company
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GeneTex |
Application
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IP, Western Blot |
Conjugation
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Immunogen
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Contents
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Catalog Number | GTX18014 | Product Name | VAMP2 antibody | Product Description | Rabbit polyclonal to VAMP2 | Synonyms | 6844 | VAMP2 | 185881 | P63027 | SYB2 | VAMP-2 | | Background | Vesicle-associated membrane protein (VAMP), is an 18kD integral membrane protein localized to the cytoplasmic surface of synaptic vesicle. VAMP consists of a proline-rich amino-terminal region, a highly conserved hydrophilic domain, followed by a transmembrane anchor and a carboxylterminal tail. Two VAMP homologs, VAMP1 and VAMP2, are differentially expressed in the nervous system. VAMP1 expression is localized to neurons involved in modulating overlapping patterns, whereas VAMP2 is found in neurons associated with autonomic, sensory and integrative functions. In non-neuronal tissues, VAMP1 is restricted to pancreas and kidney tubular cells, whereas VAMP2 is predominantly expressed in Langerhans islets and glomerular cells. Evidences for VAMPs involvement in vesicular transport and neurotransmission include the requirement of its yeast homologs, SNC 1 and 2, in targeting and fusion of Golgi derived vesicles with the plasma membrane. VAMP is also the target of clostridial neurotoxins that block neurotransmitter release from presynaptic terminals. | Clonality | Polyclonal | Host | Rabbit | Isotype | IgG | Immunogen | Synthetic peptide: QAQVDEVVDIMRVNVDKVLER conjugated to KLH, corresponding to amino acids 36-56 of Rat VAMP2. This sequence is identical to mouse, human, and bovine over these residues. | Antigen Species | Human | Tested Applications | Immunoprecipitation, Western blot. The usefulness of this product in other applications has not been determined. | Application Note | For IP: Use at a dilution of 1:50 - 1:150. For WB: Use at a dilution of 1:1,900 - 1:2,100. Detects a band of approximately 18 kDa (predicted molecular weight: 13.92 kDa). Not tested in other applications. Optimal dilutions/concentrations should be determined by the researcher. | Species Cross Reactivity | Human, mouse, rat, Xenopus laevis, cow and Guinea pig - Not tested in other species | Positive Controls | Rat brain tissue extract | Target | VAMP2 | Cellular Localization | Type IV membrane protein. Neuronal synaptic vesicles | Form Supplied | Liquid | Purification | Unpurified | Storage Buffer | No preservatives added | Storage Instruction | Upon Receipt - Keep as concentrated solution. Aliquot and store at -20¨¬C or below. Avoid freeze-thaw cycles. | |
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