| Catalog Number | GTX104402 |
| Product Name | 3-hydroxyanthranilate 3,4-dioxygenase antibody |
| Full Name | 3-hydroxyanthranilate 3,4-dioxygenase |
| Product Description | Rabbit polyclonal antibody to HAAO (3-hydroxyanthranilate 3,4-dioxygenase) |
| Synonyms | 3-HAO | HAO |
| Background | 3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. [provided by RefSeq] |
| Clonality | Polyclonal |
| Host | Rabbit |
| Immunogen | Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 228 of Human HAAO |
| Antigen Species | Human |
| Tested Applications | WB. The usefulness of this product in other applications has not been determined. |
| Application Note | Suggested starting dilutions are as follows. WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user. |
| Specificity | This antibody is specific to the Human HAAO protein. |
| Species Cross Reactivity | Human - Not yet tested in other species |
| Positive Controls | HepG2 |
| Target | HAAO |
| Predicted Target Size(KDa) | 32.56 |
| Cellular Localization | Cytoplasm |
| Form Supplied | Liquid |
| Concentration | 1 mg/ml |
| Purification | Purified by antigen-affinity chromatography. |
| Storage Buffer | 0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative. |
| Storage Instruction | Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
Image:GTX104402 WB ImageSample(30 μg of whole cell lysate)A:Hep G2(GTX27900)12% SDS PAGEGTX104402 diluted at 1:500Print:Print
